Publicaciones indexadas últimos 5 años Instituto de Química y Bioquímica

  1. Jeanluc Bertrand, Hana Dostálová, Vladimír Kryštof, Radek Jorda, Alejandro Castro, Jaime Mella, Christian Espinosa-Bustos, Ana María Zarate, Cristian O.Salas, New 2,6,9-trisubstituted purine derivatives as Bcr-Abl and Btk inhibitors and as promising agents against leukemia, October 2019, 103361, In Press, Bioorganic Chemistry (
  2. Dorador, C., Molina, V., Hengst, M., Eissler, Y., Cornejo, M., Fernández, C., Pérez, V. 2019. Microbial communities composition, activity and dynamics at Salar de Huasco, a polyextreme environment in the Chilean Altiplano. In: Extremophile microbial ecosystems in central Andes extreme environments. ME Farias (Ed). Springer, series: Cellular Origin, Life in Extreme Habitats and Astrobiology.
  3. Espinosa-Bustos, C.; Mella, J.; Soto-Delgado, J.; Salas, C. O., State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures. Future Med Chem 2019, 11, (6), 615-636.
  4. González-Gutiérrez, J.P.; Pessoa-Mahana, H.A.; Iturriaga-Vásquez, P.E.; Reyes-Parada, M.I.; Guerra-Díaz, N.E.; Hodar-Salazar, M.; Viscarra, F.; Paillali, P.; Núñez-Vivanco, G.; Lorca-Carvajal, M.A.; Mella-Raipán, J.; Zúñiga, M.C. Synthesis of Novel Nicotinic Ligands with Multimodal Action: Targeting Acetylcholine α4β2, Dopamine and Serotonin Transporters. Molecules 2019, 24, 3808 (
  5. Lorca, M.; Valdes, Y.; Chung, H.; Romero-Parra, J.; Pessoa-Mahana, C. D.; Mella, J., Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for the Design of New Cannabinoid Ligands. Int J Mol Sci 2019, 20(10), 2510.
  6. Rozas, C.; Simpson, S.; Fuentes-Retamal, S.; Catalan, M.; Ferreira, J.; Theoduloz, C.; Mella, J.; Cabezas, D.; Cassels, B. K.; Yanez, C.; Castro-Castillo, V., Antiproliferative and proapoptotic activities of aza-annulated naphthoquinone analogs. Toxicol In Vitro 2019, 54, 375-390.
  7. -Lira, C.; Alzate-Morales, J. H.; Paulino, M.; Mella-Raipan, J.; Salas, C. O.; Tapia, R. A.; Soto-Delgado, J. 2018 Combined molecular modelling and 3D-QSAR study for understanding the inhibition of NQO1 by heterocyclic quinone derivatives. Chem. Biol. Drug. Des., 91, (1), 29-38.​
  8. Lorca, M.; Morales-Verdejo, C.; Vásquez-Velásquez, D.; Andrades-Lagos, J.; Campanini-Salinas, J.; Soto-Delgado, J.; Recabarren-Gajardo, G.; Mella, J. 2018 Structure-Activity Relationships Based on 3D-QSAR CoMFA/CoMSIA and Design of Aryloxypropanol-Amine Agonists with Selectivity for the Human β3-Adrenergic Receptor and Anti-Obesity and Anti-Diabetic Profiles. Molecules , 23, 1191.
  9. Molina, V., C Dorador, C Fernández, L Bristow, Y Eissler, M Hengs, K Hernandez, LM Olsen, C Harrod, F Marchant, C Anguita, M Cornejo. 2018. The activity of nitrifying microorganisms in a high altitude Andean wetland. FEMS Microbiology Ecology. 94, 2018, fiy062. doi: 10.1093/femsec/fiy062
  10. Molina V, Eissler Y, Cornejo M, Galand PE, Dorador C, Hengst M, Fernandez C, Francois JP. 2018. Distribution of greenhouse gases in hyper-arid and arid areas of northern Chile and the contribution of the high altitude wetland microbiome (Salar de Huasco, Chile). Antonie van Leeuwenhoek, 1-12.
  11. Paul E. D. Soto Rodriguez, Fernanda Olivares, Santiago Gómez-Ruiz, Gustavo Cabrera, Reynaldo Villalonga, Rodrigo Segura del Río 2018 “Functionalized carbon nanotubes decorated with fluorine-doped titanium dioxide nanoparticles on silicon substrate as template for titanium dioxide film photo-anode grown by chemical vapour deposition”, Thin Solid Film  (en prensa).
  12. Sierra Diego, Claudia Contreras, Javier Francos, Johana Gómez, Victorio Cadierno. 2018, Novel ferrocenylphosphino sulfonates: Synthesis, crystal structure and preliminary application as ligands in aqueous catalysis. Journal of Organometallic Chemistry, 854, 106–112.
  13. Sierra Diego, Germán Brito, Mauricio Fuentealba, A. Hugo Klahn. 2018. Dicyclohexylphosphino cyrhetrene: Synthesis, characterization and catalytic evaluation toward Suzuki-Miyaura cross-coupling reaction of aryl bromides and chlorides. Inorganic Chemistry Communications, 88, 30–33.
  14. Apablaza, G.; Montoya, L.; Morales-Verdejo, C.; Mellado, M.; Cuellar, M.; Lagos, C. F.; Soto-Delgado, J.; Chung, H.; Pessoa-Mahana, C. D.; Mella, J2017. 2D-QSAR and 3D-QSAR/CoMSIA  Studies on a Series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-Phenylethan-1-ol with Human beta(3)-Adrenergic Activity. Molecules, 22, 404.
  15. Cañete-Molina, A.; Espinosa-Bustos, C.; González-Castroa, M.; Faúndez, M.; Mella, J.; Tapia, R.; Cabrera, A.; Brito, I.; Aguirre, A.; Salas, C. 2017 Design, synthesis, cytotoxicity and 3D-QSAR analysis of new 3,6-disubstitued-1,2,4,5-tetrazine derivatives as potential antitumor agents. Arab. J. Chem., In Press (
  16. Estévez Rosana A ; Miriam G Contreras Mostazo; Eduardo Rodriguez; Juan C Espinoza; Juan Kuznar; Zophonías O Jónsson; Guðmundur H Guðmundsson. 2017. Inducers of Salmon Innate Immunity: an in vitro and in vivo Approach. Fish and Shellfish Immunology, Vol 72: 247-258.
  17. Ferrer-Pertuz, K.; Espinoza, L. Mella, J. 2017 Insights into the Structural Requirements of Potent Brassinosteroids as Vegetable Growth Promoters Using Second-Internode Elongation as Biological Activity: CoMFA and CoMSIA Studies. Int J Mol Sci , 18, (12).
  18. Gómez Johana, A. Hugo Klahn, Mauricio Fuentealba, Diego Sierra, Claudio Olea-Azar, Juan D. Maya, Manuela E. Medina. 2017. Ferrocenyl and cyrhetrenyl azines containing a 5 nitroheterocyclic moiety: Synthesis, structural characterization, electrochemistry and evaluation as anti-Trypanosoma cruzi agents. Journal of Organometallic Chemistry, 839, 108-115.
  19. Gómez H., G. Riveros, D. Ramírez. 2017. “Chronoamperometric Cu(II) analysis at gold ultramicroelectrodes in concentrated sulfuric acid solutions”. Int. J. Electrochem. Sci., 12 985 – 993. DOI: 10.20964/2017.02.09
  20. Henriquez Ricardo, C. Gonzalez, J. Correa-Puerta, V. Del Campo, L. Moraga, M. Flores, S. Donoso, F. Marín, S. Bravo, R. Segura, P. Häberle 2017 “Effect of electron-surface scattering and thiol adsorption on the electrical resistivity of metallic ultra thin films”, Applied Surface Science, 407, 322-327.
  21. Hernández L. A., Riveros G., Martín F., González D. M., Lopez M. C., León M. 2017 Enhanced morphology, crystallinity and conductivity of poly (3,4-ethyldioxythiophene)/ErGO composite films by in situ reduction of TrGO partially reduced on PEDOT modified electrode, Electrochimica Acta, 155- 162.
  22. León, A. Reuquen, P., C. Garin, R. Segura, P. Vargas, P.A. Zapata, P. A. Orihuela 2017 “FTIR and Raman characterization of TiO2 nanoparticles coated with polyethylene glycol as carrier for 2-methoxyestradiol”, Applied Sciences MDPI, 7, 49, 1-9.
  23. Mella J., Francisco Villegas, César Morales-Verdejo, Carlos F. Lagos, Gonzalo Recabarren-Gajardo. 2017. Structure-activity relationships studies on weakly basic N-arylsulfonylindoles with an antagonistic profile in the 5-HT6 receptor. Journal of Molecular Structure, Vol 1139, p.362-370.
  24. Mellado, M.; Madrid, A.; Martínez, Ú.; Mella, J.; Salas, C. O.; Cuellar, M. 2017 Hansch’s analysis application to chalcone synthesis by Claisen–Schmidt reaction based in DFT methodology (doi:10.1007/s11696-017-0316-3). Chemical Papers.
  25. Oyarce J., Hernández L. A, Ahumada G., Soto J. P., del Valle M. A., Dorcet V., Carrillo D., Hamon J., Manzur C. 2017 Thiophene-containing β-diketonate complex of copper(II): X-ray crystal structure and electropolymerization, Polyhedron, 277–284.
  26. Parra C., T. Cunha, A. Contryman, D. Kong, F. Montero-Silva, P. Henrique,  D. Dos Reis,  P. Giraldo-Gallo, R. Segura, F. Olivares, F. Niestemski, H. Manoharan, R. Paniago 2017 “Phase Separation of Dirac Electrons in Topological Insulators at the Spatial Limit”, Nano Letters, 17, 97-103.
  27. Ramírez D., K. Álvarez, G. Riveros, B. González, E. A. Dalchiele. 2017. “Electrodeposition of CuSCN seed layers and nanowires: A microelectrogravimetric approach. Electrochim. Acta, 228 308 – 318. DOI: 10.1016/j.electacta.2017.01.053
  28. Ramírez D., G. Riveros, K. Álvarez, B. González, C. J. Pereyra, E. A. Dalchiele, R. E. Marotti, D. Ariosa, F. Martín, J. R. Ramos Barrado. 2017 “Electrochemical synthesis of CuSCN nanostructures, tuning the morphological and structure characteristics: From nanorods to nanostructured layers”. Mater. Sci. Semicond. Process., 68, 226–237. DOI: 10.1016/j.mssp.2017.06.030
  29. Romero-Parra, J, Hery Chung, Ricardo A. Tapia, Mario Faúndez, Cesar Morales-Verdejo, Marcos Lorca, Carlos F. Lagos, Vincenzo Di Marzo, C. David Pessoa-Mahana and  Jaime Mella. 2017. Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor. European Journal of Pharmaceutical Sciences, 101, 1-10.
  30. Sierra Diego, Johana Gomez, Vania Artigas, Mauricio Fuentealba, Andrés Muñoz, A. Hugo Klahn 2017. Reactivity of cyrhetrenylphosphines: Synthesis and characterization of oxides, boranes and selenides.. Inorganic Chemistry Communications, 76, 114–117.
  31. Tapia David, Yoanna Eissler, Juan Carlos Espinoza, Juan Kuznar. 2017. Inter-laboratory ring trial to evaluate real-time reverse transcription polymerase chain reaction methods used for detection of infectious pancreatic necrosis virus in Chile. Electronic Journal of Biotechnology 28: 20–26. DOI:
  32. del Valle M.A., Hernández L.A., Ramírez A.M., Díaz F.R. 2016 Electrosynthesis of polyquinone nanowires with dispersed platinum nanoparticles toward formic acid oxidation, Ionics, 1-9.
  33. del Valle M. A., Ramírez A. M., Hernández L. A., Armijo F., Díaz F. R., Arteaga G.C. 2016 Influence of the Supporting Electrolyte on the Electrochemical Polymerization of 3,4-Ethylenedioxythiophene. Effect on p- and n-Doping/Undoping, Conductivity and Morphology, international Journal of Electrochemical Science, 11 7048 – 7065.
  34. González B., del Valle M. A., Díaz F. R., Espinosa-Bustos C., Ramírez A. M., Hernández L. A. 2016 Synthesis, characterization, electropolymerization, and posible utilities of a new ruthenium–thiophene complex, Journal Applied Polymer Science, 1-7
  35. Hernández, L.A. M.A. del Valle, F. Armijo 2016 Electrosynthesis and characterization of nanostructured polyquinone for use in detection and quantification of naturally occurring dsDNA, Biosensors and Bioelectronics, 79 280-287.
  36. Jorquera E; Morales P; Tapia D; Torres P; Eissler Y; Espinoza JC; Conejeros P; Kuznar J. 2016. Chilean IPNV isolates: robustness analysis of PCR detection. Journal of Biotechnology (29) 28-32.
  37. Mella-Raipán J. 2016. Rational design, synthesis, biological evaluation and quantitative structure-activity relationships of novel ß3-AR ligands. Rev. Farmacol. Chile, 9(2), 32-38.
  38. Molina V, Hernández K, Dorador C, Eissler Y, Hengst M, Pérez V and Harrod C. 2016 Bacterial Active Community Cycling in Response to Solar Radiation and Their Influence on Nutrient Changes in a High-Altitude Wetland. Frontiers in Microbiology, Volume 7, Article 1823. doi: 10.3389/fmicb.2016.01823
  39. Riveros G., C. Baez, D. Ramírez, C. J. Pereyra, R. E. Marotti, R. Romero, F. Martín, J. R. Ramos-Barrado, E. A. Dalchiele. 2016 “Electrodeposition and characterization of composition-graded CdSxSe(1–x) multilayer thin film structures”. J. Alloys Compd., 686 235–244. DOI: 10.1016/j.jallcom.2016.06.010
  40. Riveros G., M. León, D. Ramírez.  2016. “Effect of chloride ions on the structural, optical, morphological, and electrochemical properties of Cu2O films electrodeposited on fluorine-doped tin oxide substrate from a DMSO solution”. J. Chil. Chem. Soc., 61 3219 – 3223. DOI: 10.4067/S0717-97072016000400014
  41. Romero-Parra, J.; Mella-Raipan, J.; Palmieri, V.; Allara, M.; Torres, M. J.; Pessoa-Mahana, H.; Iturriaga-Vasquez, P.; Escobar, R.; Faundez, M.; Di Marzo, V.; Pessoa-Mahana, C. D. 2016. Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor. European journal of medicinal chemistry, 124, 17-35.
  42. Segura, R. A.  F. Olivares, J. Maze, P. Häberle, R. Henríquez 2016 “Photoelectrochemical Activity of Graphene Supported Titanium Dioxide”, Journal of Nanomaterials, 7914189, 1-6.
  43. Torres P, Eissler Y, Tapia D, Espinoza JC & Kuznar J 2016. Genotipificación y relación hospedador-específica del virus de la necrosis pancreática infecciosa en Chile. Genotyping and host-specific relationship of infectious pancreatic necrosis virus in Chile Lat. Am. J. Aquat. Res., 44(4): 860-868, 2016. DOI: 10.3856/vol44-issue4-fulltext-23.
  44. Vera, G.; Lagos, C. F.; Almendras, S.; Hebel, D.; Flores, F.; Valle-Corvalan, G.; Pessoa-Mahana, C. D.; Mella-Raipan, J.; Montecinos, R.; Recabarren-Gajardo, G. 2016. Extended N-Arylsulfonylindoles as 5-HT(6) Receptor Antagonists: Design, Synthesis & Biological Evaluation. Molecules, 21.​
  45. Andrades, J. Javier Campanini, David Vásquez, Cristoforo Silvestri, César Morales, Javier Romero and Jaime Mella. 2015 A combined CoMFA and CoMSIA 3D-QSAR study of benzamide type antibacterial inhibitors of the FtsZ protein in drug-resistant Staphylococcus aureus.Sar Qsar Environ Res, 26(11):1-18.
  46. del Valle M. A., Hernández L. A., Díaz F. R., Ramos A. 2015 Electrosynthesis and Characterization of Poly(3,4-ethylenedioxythiophene) Nanowires, International Journal of Electrochemical Science, 10 5152-5163.
  47. Espinosa-Bustos, C., Javier Romero-Parra, Ana M. Zárate, Jaime Mella-Raipán, Hernán Pessoa-Mahana, Patricio Iturriaga-Vásquez, Ricardo A. Tapia, Carlos F. Lagos and C. David Pessoa-Mahana. 2015. Synthetic cannabinoid ligands: a new series of benzimidazole-based molecules with significant binding affinity for CB1 receptors. Arch. Pharm. Chem. Life Sci. 348, 1–8.
  48. Gómez Johana, A. Hugo Klahn, Mauricio Fuentealba, Diego Sierra, Claudio Olea-Azar, Manuela E. Medina. 2015. Unsymmetrical cyrhetrenyl and ferrocenyl azines derived from 5-nitrofurane: Synthesis, structural characterization and electrochemistry. Inorganic Chemistry Communications, 61, 204–206.
  49. González B.,. del Valle M.A, Díaz F.R., Espinosa-Bustos C., Ramírez A., Hernández L.A. 2015 Synthesis and electrochemical characterization of new ruthenium-terthiophene complexes, Polyhedron, 89 232-237.
  50. Hernández L.A., del Valle M.A., Díaz F.R., Fermin D.J., Risbridger T.A.G. 2015 Polymeric nanowires directly electrosynthesized on the working electrode, Electrochimica Acta, 166 163-167.
  51. Lakhdar Toumi A., Khelil A., Tobel K.,. Makha M, Hernández L.A., Mouchaal Y., Cattin L., del Valle M.A., Diaz F.R., Bernède J.C. 2015 On the exciton blocking layer at the interface organic/cathode in planar multiheterojunction organic solar cells, Solid-State Electronics, 104 1-5.
  52. Ortega E., Díaz F. R., Hernández L. A., del Valle M.A. 2015 Polyanilines Modified Electrodes to be Assayed as Halides Sensors International Journal of electrochemical science, 10 2707-2715.
  53. Riveros G., C. Garín, D. Ramírez, E.A. Dalchiele, R.E. Marotti, C.J. Pereyra, E. Spera, H. Gómez, P. Grez, F. Martín, J.R. Ramos-Barrado. 2015 “Delafossite CuFeO2 thin films electrochemically grown from a DMSO based solution”. Electrochim. Acta 164 297–306. DOI: 10.1016/j.electacta.2015.02.226
  54. Tapia, D, Eissler, Y, P. Torres, E. Jorquera, J. C. Espinoza, J. Kuznar 2015 Detection and phylogenetic analysis of infectious pancreatic necrosis virus in Chile. Diseases of aquatic organisms. Vol. 116: 173–184, doi: 10.3354/dao02912
  55. del Valle M.A., Ramos A.C., Antilen M.P., Hernandez L.A., Arteaga G.C., Diaz F.R., Louarn G. 2014 Electro-synthesis and characterization of polymer nanostructures from terthiophene using silica mesoporous films as template, Electrochemistry, 82 146-151.
  56. del Valle M.A., Llanquileo P., Díaz F.R., Faúndez M., Hernández L.A., González B. 2014 Design and evaluation of a Hg(II) sensor based on the response of a poly(3,4- ethylenedioxythiophene) modified electrode, Journal of the Chilean Chemical Society, 59 2481-2484.
  57. Hevia S. A., R. Segura, P. Häberle 2014 “Low energy electrons focused by the image charge interaction in carbon nanotubes”, Carbon, 80: 50–58.
  58. Mella-Raipán J. Santiago Hernández-Pino, César Morales-Verdejo, David Pessoa-Mahana. 2014 3D-QSAR/CoMFA-Based Structure-Affinity/Selectivity Relationships of Aminoalkylindoles in the Cannabinoid CB1 and CB2 Receptors. Molecules, 19(3), 2842-2861.
  59. Ortega Cesar, Sylvia Rodríguez, Juan Espinoza, Juan Kuznar, Alex Romero, Ricardo Enríquez. 2014. Relación entre apoptosis y secuencia del dominio bh2 del peptido vp5 del virus de la necrosis pancreática infecciosa. Revista MVZ Córdoba. 19(1):3990-4002.
  60. Ramírez D., K. Álvarez, G. Riveros, M. Tejos, M. G. Lobos.  2014 New Insights on the Doping of ZnO Films with elements from group IIIA through Electrochemical Deposition.” J. Solid. State Electrochem., 18, 2869–2884. DOI: 10.1007/s10008-014-2558-0
  61. Riveros G., D. Ramírez, E. A. Dalchiele, R. Marotti, P. Grez, F. Martín, J. R. Ramos-Barrado. 2014 “Electrodeposition and Characterization of Hematite Films Obtained from DMSO Solution”. J. Electrochem. Soc., 161, D353–D361. DOI: 10.1149/2.098406jes
  62. Segura R. A., C. Contreras, R. Henriquez, P. Häberle, J. J. Sáez, A. Adrian, P. Alvarez, S. Hevia 2014 “Gold nanoparticles grown inside carbon nanotubes: synthesis and electrical transport measurements”, Nanoscale Research Letters, 9: 207.
  63. Sierra Diego, Nattamai Bhuvanesh, Joseph H. Reibenspies, John A. Gladysz, A. Hugo Klahn. 2014. Syntheses, structures, and reactions of cyrhetrenylphosphines; applications in palladium catalyzed Suzuki cross-coupling reactions. Journal of Organometallic Chemistry, 749, 416–420.
  64. Grez P., F. Herrera, G. Riveros, R. Henríquez, A. Ramírez, E. Muñoz, E.A. Dalchiele, C. Celedón, R. Schrebler. 2013 “Synthesis and characterization of p-Cu2O nanowires arrays” Mater. Lett 92, 413–416. DOI: 10.1016/j.matlet.2012.11.012
  65. Gómez H., S. Cantillana, G. Riveros, S. Favre, C. J. Pereyra, D. Ariosa, R. E. Marotti, E. A. Dalchiele.  2013 “Growth of Epitaxial Zinc Oxide Thin Films onto Gallium Nitride by Electrodeposition from a Dimethylsulfoxide Based Electrolytic Solution” Int. J. Electrochem. Sci., 8, 10149 – 10162.
  66. Mella-Raipán, J., Carlos F. Lagos, Gonzalo Recabarren-Gajardo, Christian Espinosa-Bustos, Javier Romero-Parra, Hernán Pessoa-Mahana, Patricio Iturriaga-Vásquez, and C. David Pessoa-Mahana. 2013. Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles—A New Family of High Affinity CB1 Cannabinoid Ligands. Molecules, 18 (4), 3972-4001.
  67. Riveros G., A. Garmendia, D. Ramírez, M. Tejos, P. Grez, H. Gómez and E. A. Dalchiele. 2013. “Study of the Electrodeposition of Cu2O Thin Films from DMSO Solution” J. Electrochem. Soc., 160, D28–D33. DOI: 10.1149/2.029302jes
  68. Valdés, J. E., C. Celedón, R. Segura, I. Abril, R. Garcia-Molina, C. D. Denton, N. R. Arista, P. Vargas, 2013 “Energy loss distribution of proton beams at normal incidence on multi-walled carbon nanotubes” Carbon, 52: 137-144.

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